Automated Creation of Clinical-practice Guidelines from Decision Models a Dissertation Submitted to the Program in Medical Information Sciences and the Committee on Graduate Studies of Stanford University in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy

....................................................................................................................... v Acknowledgments ....................................................................................................... ix Table of contents .......................................................................................................xiii List of tables .............................................................................................................. xix List of figures............................................................................................................. xxi Chapter 1 Automated Creation of Clinical-Practice Guidelines from Decision Models 1.1 Hypothesis .............................................................................................................. 2 1.2 Clinical-practice guidelines................................................................................... 5 1.3 Evidence-based guidelines .................................................................................... 5 1.4 Problems in the development of clinical-practice guidelines............................. 6 1.5 Decision models...................................................................................................... 7 1.6 Overview of ALCHEMIST architecture .................................................................. 8 1.7 Conceptual-model framework............................................................................ 10 1.8 Conceptual model for CPGs ............................................................................... 10 1.9 Conceptual model for decision models .............................................................. 11 1.10 Mapping between DM and CPG representations........................................... 13 1.11 Tailoring of CPGs.............................................................................................. 14